Make sure only the right processes can access the profile path.

chrome/app/generated_resources.grd

 <?xml version="1.0" encoding="UTF-8"?>
 
 <!--
 This file contains definitions of resources that will be translated for each
 locale.  The variables is_win, is_macosx, is_linux, and is_posix are available
 for making strings OS specific.  Other platform defines such as use_titlecase
 are declared in build/common.gypi.
 -->
 
 <grit base_dir="." latest_public_release="0" current_release="1"
@@ skipping 9710 matching lines @@
 Your profile could not be opened correctly.
 
 Some features may be unavailable.  Please check that the profile exists and you have permission to read and write its contents.
       </message>
       <message name="IDS_REFUSE_TO_RUN_AS_ROOT" desc="Short error message in displayed in an error dialog on startup if the user tries to run chrome as root">
         <ph name="PRODUCT_NAME">$1<ex>Google Chrome</ex></ph> can not be run as root.
       </message>
       <message name="IDS_REFUSE_TO_RUN_AS_ROOT_2" desc="Detailed message in the error dialog when the user tries to start chrome as root">
         Please start <ph name="PRODUCT_NAME">$1<ex>Google Chrome</ex></ph> as a normal user. To run as root, you must specify an alternate --user-data-dir for storage of profile information.
       </message>
+      <message name="IDS_PROFILE_ON_NETWORK_WARNING" desc="Warning shown to the user in a dialog box when he is running Chrome on Windows with a profile located on a network share.">
+Your browser is running with a profile located on a non-local drive. This configuration is not fully supported and might not work reliably. 
+        
+Consider switching to profile stored on a local drive for optimal experience.
+      </message>
 
       <!-- Can't write to user data directory dialog -->
       <message name="IDS_CANT_WRITE_USER_DIRECTORY_TITLE" desc="Title of dialog that is displayed when we can't create a directory for this user.">
         Failed To Create Data Directory
       </message>
       <message name="IDS_CANT_WRITE_USER_DIRECTORY_CHOOSE_DIRECTORY_BUTTON" desc="Text on button that opens another dialog to choose a new directory for user data.">
         Choose Another Directory...
       </message>
 
       <!-- Advanced Section Titles -->
@@ skipping 5131 matching lines @@
     </messages>
     <structures fallback_to_english="true">
       <!-- Make sure these stay in sync with the structures in generated_resources.grd. -->
       <structure name="IDD_CHROME_FRAME_FIND_DIALOG" file="cf_resources.rc" type="dialog" >
       </structure>
       <structure name="IDD_CHROME_FRAME_READY_PROMPT" file="cf_resources.rc" type="dialog" >
       </structure>
     </structures>
   </release>
 </grit>